Research News

Research News

Jacy Wagnon, PhD Ohio State College of Medicine

Targeting Molecular Responses to Seizures in Dravet Syndrome

Jacy Wagnon, PhD – The Ohio State University College of Medicine $150,000 TWO YEAR RESEARCH AWARD Many individuals with Dravet syndrome (DS) do not achieve adequate seizure control using available drug treatments. These drugs also do not sufficiently treat other symptoms of DS, including behavioral and cognitive impairments. We analyzed gene expression in a mouse […]

Targeting Molecular Responses to Seizures in Dravet Syndrome Read More »

Manisha N. Patel, PhD – University of Colorado and Kelly G. Knupp, MD – Children’s Hospital Colorado

Lymphoblast cell lines as a model to uncover metabolic defects in Dravet syndrome

Manisha N. Patel, PhD – University of ColoradoKelly G. Knupp, MD – Children’s Hospital Colorado $150,000 TWO YEAR RESEARCH AWARD Dravet syndrome (DS) is a catastrophic developmental and epileptic encephalopathy characterized by intractable early-life seizures, and debilitating comorbidities such as cognitive deficits, developmental delay, sleep disturbances, progressive movement abnormalities and increased risk of sudden unexpected

Lymphoblast cell lines as a model to uncover metabolic defects in Dravet syndrome Read More »

Monarch Dravet syndrome study

MONARCH Trial Update

Phase 1/2a MONARCH clinical trial of STK-001 update Stoke Therapeutics released interim safety, pharmacokinetic, and CSF exposure data from their Phase 1/2a MONARCH trial of STK-001 in individuals with Dravet syndrome. • The data in this analysis comes from 21 patients in the Single Ascending Dose arm of the study (SAD: 1 dose with a

MONARCH Trial Update Read More »

PAME 21

PAME Memory Wall

Partners Against Mortality in Epilepsy Memory Wall Partners Against Mortality in Epilepsy (PAME) is a collaboration among health care providers, clinical researchers, basic scientists, public health officials, patient advocates, caregivers, bereaved families, and people living with epilepsy. This range of stakeholders come together with a common goal of improving our understanding of and working to

PAME Memory Wall Read More »

Surgery Procedures & Dravet Syndrome, Surgery & Doctor graphic

Surgery & Procedures

Surgery & Procedures in Dravet Syndrome Patients with Dravet syndrome often require a surgery or other invasive procedure at some point in their life. While there are no specific surgical procedures that are specifically required due to the diagnosis of Dravet syndrome, there are some procedures that occur more commonly, including: feeding tube placement (i.e.,

Surgery & Procedures Read More »

Woman researcher using microscope in lab

Review of: Enhancing glucose metabolism via gluconeogenesis is therapeutic in a zebrafish model of Dravet syndrome

Banerji et al (2021) recently published a manuscript in Brain Communications describing their investigation of metabolic pathways in a zebrafish model of Dravet syndrome. Previous studies had described metabolic deficits in Dravet syndrome generally related to decreased energetic output. The ketogenic diet remains one of the more successful therapies for seizure reduction in Dravet syndrome,

Review of: Enhancing glucose metabolism via gluconeogenesis is therapeutic in a zebrafish model of Dravet syndrome Read More »

Now enrolling doctor cartoon graphic

New Study for Adults

New Study Opportunity for Adults with Dravet Syndrome Dr. Danielle Andrade, an adult neurologist who is an expert in Dravet syndrome (DS), is currently conducting a study of adults with DS to improve the understanding of seizures, symptoms, comorbidities, and daily life as patients age. Part of the study is examining patients that visit Dr.

New Study for Adults Read More »

Scroll to Top

Join us at a Day of Dravet workshop

Skip to content