Research News

Danielle Andrade, MD, MSc, FRCPC, CSCN- University of Toronto Prospective Study of Accelerated Aging in Adults with Dravet SyndromeTransformational Science Grant- $499,455 over 3 years Summary from the Investigator: Dravet syndrome is a rare and serious form of epilepsy that begins in infancy. Thanks to better medical care, most people with Dravet live into adulthood. […]

Professor Andreas Brunklaus, MD, MRCPCH- Royal Hospital for Children GlasgowCharlotte Tye, PhD- King’s College LondonElaine Wirrell, MD- Mayo ClinicLaureate Professor Ingrid Scheffer AO MBBS PhD FAA FAHMS FRS- University of Melbourne, Austin Health and Royal Children’s Hospital, Florey and Murdoch Children’s Research Institutes, Melbourne, AustraliaDennis Lal, PhD- UT Health Houston Predicting Dravet syndrome outcomes: harnessing

Ethan M. Goldberg, MD, PhD- The Children’s Hospital of Philadelphia Neuromodulation for Dravet Syndrome: Preclinical Validation of a Novel Therapeutic MechanismResearch Grant- $250,000 over 2 years Grant Summary from the Investigator: Children with Dravet syndrome experience epilepsy as well as comorbid psychiatric symptoms including aggression, self-injury, and mood disorder. ~ 90% of children with Dravet

Alex Nord, PhD- University of California DavisDiasynou Fioravante, PhD- University of California Davis Cell-type resolved molecular and functional pathology in Scn1a mutant mouse cerebellumResearch Grant- $249,960 over 2 years Summary from the Investigators: Dravet syndrome (DS), caused by loss of function mutations to the SCN1A gene, is characterized by refractory epilepsy accompanied by cognitive, social,

Ulrike Hedrich-Klimosch, PhD- University of Tuebingen Mapping Early Postnatal Brain Development in Dravet Syndrome Using Multimodal ApproachesResearch Grant- $248,901 over 2 years Summary from the Investigator: Dravet syndrome (DS) is a severe form of epilepsy that begins in infancy and is often resistant to treatment. It not only causes frequent seizures but also affects brain

Amanda Catalfio, PhD- University of Michigan Investigating effects of the pathogenic developmental and epileptic encephalopathy patient variant, SCN1B-p.R98C, on cognition and hippocampal functionPostdoctoral Fellowship- $75,000 over 1 year Summary from the Investigator: Dravet syndrome (DS) is a devastating developmental and epileptic encephalopathy. Symptoms include treatment-refractory epilepsy with complex cognitive and behavioral outcomes that are associated

Mahima Dewani, PhD- Brigham and Women’s Hospital, Harvard Medical School Rewriting the Brain’s Code: Nose-to-Brain Gene Therapy for SCN1A HaploinsufficiencyPostdoctoral Fellowship- $75,000 over 1 year Grant Summary from the Investigator: Dravet syndrome is a devastating form of childhood epilepsy that causes frequent, hard-to-control seizures, developmental delays, and high risk of sudden death. Current medicines help

Megumi Mori, PhD- Gladstone Institutes and University of California San Francisco Mechanisms of Seizure Prevention by Tau Reduction in Scn1aRX/+ MicePostdoctoral Fellowship- $75,000 over 1 year Recipient of the Elliot Meskis Award for an Exceptional Postdoctoral Fellow which provides a $2,500 grant supplement for professional development. Summary from the Investigator: There is currently no cure

Kelly Knupp, MD – Children’s Hospital Colorado Longitudinal Dravet Syndrome Natural History Study Special Project Funding: 3 years – $662,231 Grant Summary from the Investigators: The Dravet Lifespan Multidisciplinary Clinic at Children’s Hospital Colorado in collaboration with the Dravet Syndrome Foundation is pleased to announce the Dravet Syndrome Natural History Study.  A natural history study

Ivan Soltesz, PhD – Stanford University, Jack Parent, MD – University of Michigan, Julie Ziobro, MD, PhD- University of Michigan and Tilo Gschwind, PhD- Stanford University Identification of Behavioral Biomarkers in Children with DS: A Pilot Study Special Project Funding: 2 years – $338,750 Title: Identification of Behavioral Biomarkers in Children with Dravet Syndrome: A