2021 DSF Grant Awardees DSF is dedicated to funding the highest caliber research on Dravet syndrome and associated epilepsies. Our focus is on research projects that will find new treatments and improve the quality of life for those living with an ion channel epilepsy. We place a high priority on funding research that has a clear path to genetic understanding, clinical application, and/or therapeutic development. We are pleased to announce the 2021 Research Grant Awards. Thanks to the financial support of our community, we were able to award five new research grants totaling $650,000, bringing our total grants awarded to over $5.6M since 2009. This year, another organization, JAM for Dravet, has stepped forward to co-fund two of these projects with DSF. JAM (Julian’s Awareness Movement) for Dravet was inspired by Julian Chang, who was diagnosed with Dravet syndrome at one year old. His parents, Daniel and Deb, established the foundation to help accelerate cutting-edge pathways to a cure, raise awareness, and foster a robust community of support for families affected by Dravet syndrome. DSF appreciates their important contribution to advancing research efforts for Dravet syndrome. Research Grants – $150,000 two-year awards
- Lymphoblast cell lines as a model to uncover metabolic defects in Dravet Syndrome: Manisha N. Patel, PhD, University of Colorado, and Kelly G. Knupp, MD, Children’s Hospital Colorado.
- Ketogenic Diet Modulated Brain Energy Metabolism in Dravet Syndrome: 2H MR in a Mouse Model: K. Liu Lin Thio, MD, PhD, and Joel R. Garbow, PhD, Washington University in St. Louis. This grant was co-funded with JAM for Dravet.
- Targeting Molecular Responses to Seizures in Dravet Syndrome: Jacy Wagnon, PhD, Ohio State College of Medicine.
- Use of TMS to understand in-vivo the functional pathophysiology of DS and predict treatment response: Simona Balestrini, MD, PhD, and Sanjay Sisodiya, PhD, FRCP, UCL Queen Square Institute of Neurology, London.
- Optimizing the Regional Administration of SCN8a-targeting RNAi Therapy: Wenxi Yu, PhD, University of Michigan. This grant was co-funded with JAM for Dravet.